Xiaoyaosan ethyl acetate fraction alleviates depression-like behaviors in CUMS mice by promoting hippocampal neurogenesis via modulating the IGF-1Rβ/PI3K/Akt signaling pathway
Jiuseng Zeng, Yafei Ji, Fei Luan, Jingwen Hu, Yixin Rui, Yao Liu, Zhili Rao, Rong Liu, Nan Zeng
Topics & Concepts
Hippocampal formationDentate gyrusPI3K/AKT/mTOR pathwayBehavioural despair testHippocampusPharmacologyNissl bodyEndocrinologyProtein kinase BNeurogenesisInternal medicineAntidepressantChemistryMedicineNeuroscienceBiologyApoptosisBiochemistryPathologyStainingNeurogenesis and neuroplasticity mechanismsStress Responses and CortisolTryptophan and brain disorders