Litcius/Paper detail

Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, <i>in vitro</i> assays, and <i>in silico</i> studies

Mohamed H. Saad, Tarek F. El‐Moselhy, El-Din Nabaweya S, Ahmed B. M. Mehany, Amany Belal, Mohammed A. S. Abourehab, Haytham O. Tawfik, Mervat H. El‐Hamamsy

2022Journal of Enzyme Inhibition and Medicinal Chemistry14 citationsDOIOpen Access PDF

Abstract

, were inspected for their putative mechanism of action by estimating their epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER-2), and Bruton's tyrosine kinase (BTK) inhibitory activities. Furthermore, the antimicrobial activity of target compounds was assessed against six different pathogens, followed by determining the minimum inhibitory concentration "MIC" values for the most active analogues. Molecular docking study was achieved to understand mode of interactions between selected inhibitors and different biological targets.

Topics & Concepts

In vitroChemistryTyrosine kinaseEpidermal growth factor receptorKinaseIC50Mechanism of actionIn silicoDocking (animal)Receptor tyrosine kinaseStereochemistryADMEPharmacologyBiochemistryReceptorBiologyMedicineNursingGeneCancer therapeutics and mechanismsSynthesis and biological activityQuinazolinone synthesis and applications
Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, <i>in vitro</i> assays, and <i>in silico</i> studies | Litcius