Recent Advances in Exosome-Based Drug Delivery for Cancer Therapy
Hyo‐Suk Kim, Hochung Jang, Haeun Cho, Ji‐Won Choi, Kwang Yeon Hwang, Yeonho Choi, Sun Hwa Kim, Yoosoo Yang
Abstract
Exosomes are a class of extracellular vesicles, with a size of about 100 nm, secreted by most cells and carrying various bioactive molecules such as nucleic acids, proteins, and lipids, and reflect the biological status of parent cells. Exosomes have natural advantages such as high biocompatibility and low immunogenicity for efficient delivery of therapeutic agents such as chemotherapeutic drugs, nucleic acids, and proteins. In this review, we introduce the latest explorations of exosome-based drug delivery systems for cancer therapy, with particular focus on the targeted delivery of various types of cargoes.
Topics & Concepts
MicrovesiclesExosomeExtracellular vesiclesDrug deliveryNucleic acidImmunogenicityCancer therapyExtracellular vesicleDrugTargeted drug deliveryBiocompatibilityChemistryCancerComputational biologyBiologyNanotechnologymicroRNAPharmacologyCell biologyBiochemistryImmune systemImmunologyGeneMaterials scienceOrganic chemistryGeneticsExtracellular vesicles in diseaseRNA Interference and Gene DeliveryMicroRNA in disease regulation