Complete Absence of FAPI Uptake in a Patient With Aggressive Diffuse Large B-Cell Lymphoma Involving Multiple Nodal and Extranodal Sites
Lu Li, Bin Ji
Abstract
ABSTRACT: A 73-year-old man with histopathologically confirmed diffuse large B-cell lymphoma underwent both 18 F-FDG and 18 F-FAPI PET/CT. Although 18 F-FDG PET showed abnormally increased tracer uptake in multiple nodal sites and organs, indicating the aggressiveness of the disease status, 18 F-FAPI PET showed no obvious FAPI uptake in any of the FDG-avid lesions. Our case suggests that low expression of FAP in diffuse large B-cell lymphoma, as indicated by FAPI PET, might help determine a subgroup of patients with poorer outcome.
Topics & Concepts
MedicineLymphomaDiffuse large B-cell lymphomaNuclear medicinePathologyPET-CTNODALPositron emission tomographyInternal medicinePeptidase Inhibition and AnalysisUbiquitin and proteasome pathwaysCardiac Structural Anomalies and Repair