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Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis

Jiao Yan, Jinshan Nan, Bo Mu, Yun Zhang, Nenghua Zhou, Shunhua Yang, Shunhua Yang, Shanshan Zhang, Wan-Ting Lin, Falu Wang, Anjie Xia, Zhixing Cao, Pei Chen, Zhiling Pan, Guifeng Lin, Shulei Pan, Huachao Bin, Linli Li, Shengyong Yang, Shengyong Yang

2022European Journal of Medicinal Chemistry54 citationsDOIOpen Access PDF

Topics & Concepts

PyroptosisInflammasomeAIM2ChemistryProinflammatory cytokineCaspase 1NLRC4Programmed cell deathCell biologySignal transducing adaptor proteinIn vitroInflammationApoptosisBiochemistrySignal transductionBiologyImmunologyReceptorInflammasome and immune disordersGout, Hyperuricemia, Uric AcidHeme Oxygenase-1 and Carbon Monoxide
Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis | Litcius