Discovery of a novel and potent inhibitor with differential species-specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis
Jiao Yan, Jinshan Nan, Bo Mu, Yun Zhang, Nenghua Zhou, Shunhua Yang, Shunhua Yang, Shanshan Zhang, Wan-Ting Lin, Falu Wang, Anjie Xia, Zhixing Cao, Pei Chen, Zhiling Pan, Guifeng Lin, Shulei Pan, Huachao Bin, Linli Li, Shengyong Yang, Shengyong Yang
Topics & Concepts
PyroptosisInflammasomeAIM2ChemistryProinflammatory cytokineCaspase 1NLRC4Programmed cell deathCell biologySignal transducing adaptor proteinIn vitroInflammationApoptosisBiochemistrySignal transductionBiologyImmunologyReceptorInflammasome and immune disordersGout, Hyperuricemia, Uric AcidHeme Oxygenase-1 and Carbon Monoxide