Recent developments in the synthesis of indolizines and their derivatives as compounds of interest in medicinal chemistry: a review
Andreea Veronica Dediu Botezatu, Bianca Furdui, Anna Cazanevscaia Busuioc, Rodica Mihaela Dinică
Abstract
Indolizine scaffolds have been identified as promising structures for the development of a diverse range of functionalized compounds with a wide array of biological and pharmacological activities, such as anticancer, antibacterial, antifungal, anti-inflammatory, antiviral and anti-neurodegenerative. The functionalization of nitrogen heterocyclic scaffolds has always been a topic of interest in medicinal chemistry research and has made great progress in recent years. Functionalized indolizines have structurally diversified as molecules of interest as they offer robust applications in the fields of medicine, pharmaceutical sciences, agriculture, bioimaging, chemistry, food industry or materials science. In the literature, several conventional methods for obtaining indolizines have been established. Alternative green synthesis methods have also been proposed for the efficient formation of various N-heterocyclic scaffolds by partially or completely replacing the toxic catalysts and solvents currently used in chemical synthesis processes. This review comprises the advances made from 2017 to 2024 in the development of indolizine synthesis by both classical and non-conventional newly emerged methods, highlighting the biological properties of indolizine derivatives.