A MicroRNA Gene Panel Predicts the Vaginal Microbiota Composition
Liqin Cheng, Dominika Kaźmierczak, Johanna Norenhag, Marica Hamsten, Emma Fransson, Ina Schuppe‐Koistinen, Matts Olovsson, Lars Engstrand, Per Hydbring, Juan Du
Abstract
-dominated communities, predicted the bacterial composition of the vaginal microbiota in an independent validation group. Since targeting of microRNAs is explored in the clinical setting, our results warrant investigation of whether microRNA modulation could be used for treating vaginosis recurrence and vaginosis-related diseases. Conversely, commensal bacteria could be used for treating diseases with microRNA aberrations.
Topics & Concepts
LactobacillusBiologyVaginal infectionsmicroRNADiseaseGeneVaginaHuman papillomavirusGeneticsBacteriaMedicineInternal medicineObstetricsReproductive tract infections researchCervical Cancer and HPV ResearchReproductive System and Pregnancy