Liver injury associated with acute pancreatitis: The current status of clinical evaluation and involved mechanisms
Wei Liu, Juanjuan Du, Zenghui Li, Xinyu Zhang, Hou-Dong Zuo
Abstract
Acute pancreatitis (AP) is a very common acute disease, and the mortality rate of severe AP (SAP) is between 15% and 35%. The main causes of death are multiple organ dysfunction syndrome and infections. The mortality rate of patients with SAP related to liver failure is as high as 83%, and approximately 5% of the SAP patients have fulminant liver failure. Liver function is closely related to the progression and prognosis of AP. In this review, we aim to elaborate on the clinical manifestations and mechanism of liver injury in patients with AP.
Topics & Concepts
MedicineAcute pancreatitisFulminantMortality rateLiver injuryInternal medicineGastroenterologyPancreatitisLiver failureOrgan dysfunctionLiver functionDiseaseLiver dysfunctionFulminant hepatic failureMultiple organ dysfunction syndromeIntensive care medicineLiver transplantationSepsisTransplantationPancreatitis Pathology and TreatmentLiver Disease Diagnosis and TreatmentMuscle and Compartmental Disorders