Design, synthesis and evaluation of new 4-arylthiazole-2-amine derivatives as acetylcholinesterase inhibitors
Yuan Xu, Meng-Meng Jian, Chuang Han, Kan Yang, Ligai Bai, Fei Cao, Zheng-Yue Ma
Topics & Concepts
ChemistryAcetylcholinesteraseButyrylcholinesteraseStereochemistryRivastigmineAmine gas treatingInhibitory postsynaptic potentialIn silicoIC50In vitroEnzymeCombinatorial chemistryAchéDonepezilBiochemistryOrganic chemistryNeurosciencePathologyBiologyDementiaMedicineDiseaseGeneCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity