BATF2 inhibits the stem cell-like properties and chemoresistance of gastric cancer cells through PTEN/AKT/β-catenin pathway
Long‐Long Cao, Kai Weng, Lujie Li, Guang‐Tan Lin, Yuxuan Zhao, Youxin Gao, Xiaobo Huang, Qiyue Chen, Jiabin Wang, Chao‐Hui Zheng, Chang‐Ming Huang, Jian-Wei Xie, Ping Li
Abstract
BATF2 plays a pivotal role in regulating stem-like characteristics and chemoresistance in gastric cancer through the BATF2/PTEN/AKT/ABCG2 pathway. These findings suggest a novel therapeutic strategy targeting BATF2 to enhance chemotherapy effectiveness in gastric cancer treatment.
Topics & Concepts
PTENCancer researchCateninPI3K/AKT/mTOR pathwayProtein kinase BCancerCancer stem cellStem cellChemistryCancer cellSignal transductionBiologyMedicineInternal medicineCell biologyWnt signaling pathwayCancer-related molecular mechanisms researchCholangiocarcinoma and Gallbladder Cancer Studies