The hepatic microenvironment promotes lung adenocarcinoma cell proliferation, metastasis, and epithelial–mesenchymal transition via METTL3-mediated N6-methyladenosine modification of <i>YAP1</i>
Xuefeng Ni, Quanqin Xie, Jiemin Zhao, Yanjie Xu, Mei Ji, Wenwei Hu, Jun Wu, Changping Wu
Abstract
mRNA. These results indicate that the hepatic inflammatory microenvironment plays a role in regulating the biological functions of LUAD cells. Further, our study identifies a molecular mechanism that may provide a new strategy for the early diagnosis, treatment, and prognosis of liver metastasis in LUAD patients.
Topics & Concepts
Epithelial–mesenchymal transitionYAP1Cancer researchMetastasisChemistryMesenchymal stem cellLungTransition (genetics)Tumor microenvironmentCell growthCell biologyBiologyInternal medicineMedicineTumor cellsCancerBiochemistryTranscription factorGeneCancer-related gene regulationRNA modifications and cancerHippo pathway signaling and YAP/TAZ