Memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and BDNF signaling pathways in prediabetic mice
Vanessa Angonesi Zborowski, Suélen O. Heck, Luiza Souza Marques, Nícolas Klummer Bastos, Cristina W. Nogueira
Topics & Concepts
Morris water navigation taskEndocrinologyInternal medicineGLUT4PrediabetesCREBHippocampal formationDownregulation and upregulationHippocampusMedicineInsulinTropomyosin receptor kinase BTail suspension testDiabetes mellitusMemory impairmentBehavioural despair testInsulin resistanceType 2 diabetesBiologyNeurotrophic factorsPsychiatryAntidepressantReceptorGeneBiochemistryCognitionTranscription factorNeuroinflammation and Neurodegeneration MechanismsPancreatic function and diabetesRegulation of Appetite and Obesity