Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes
Jibo Han, Zimin Fang, Bingjiang Han, Bozhi Ye, Wante Lin, Yucheng Jiang, Xue Han, Xu Wang, Gaojun Wu, Yi Wang, Guang Liang
Topics & Concepts
Muscle hypertrophyDownregulation and upregulationEndoplasmic reticulumHypertrophic cardiomyopathyInternal medicineEndocrinologyCalciumMyocyteDeubiquitinating enzymeUbiquitinMedicineBiologyCell biologyGeneBiochemistryUbiquitin and proteasome pathwaysEndoplasmic Reticulum Stress and DiseaseCardiomyopathy and Myosin Studies