VEXAS Syndrome—Diagnostic Clues for the Dermatologist and Gaps in Our Current Understanding: A Narrative Review
Lowell T. Nicholson, Edward W. Cowen, David B. Beck, Marcela A. Ferrada, Lauren M. Madigan
Abstract
Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic syndrome is a newly recognized, acquired autoinflammatory disorder with broad systemic implications and a poor global prognosis. Because cutaneous lesions are present in the majority of those affected, it is necessary that dermatologists are equipped to recognize this important disease. Through identification, there is a greater opportunity for disease stratification, surveillance for systemic involvement, and selection of the best available therapies. As our understanding of this disease develops, dermatologists should also play a role in addressing the knowledge gaps that exist.
Topics & Concepts
DiseaseNarrative reviewDermatologyMedicineNarrativeIdentification (biology)Selection (genetic algorithm)Intensive care medicinePathologyBiologyComputer sciencePhilosophyBotanyArtificial intelligenceLinguisticsOtitis Media and Relapsing PolychondritisVascular Anomalies and TreatmentsCongenital Ear and Nasal Anomalies