Catalytic π–π Interactions Triggered Photoinduced Synthesis of Biaryls
Vishal Jyoti Roy, Janardan Chakraborty, Sudipta Raha Roy
Abstract
A highly regioselective photocatalytic method to access a variety of biaryl motifs under metal-free conditions has been developed. The organophotocatalyst is involved in π-π stacking interactions with the alkyne species, which promotes this photocatalytic process with thiophene. Mechanistic studies have shed light on these interactions and the overall process. Along with a broad functional-group tolerance and excellent regioselectivity, this protocol has been utilized in the late-stage functionalization of pharmaceuticals and other natural products.
Topics & Concepts
RegioselectivityChemistryStackingCatalysisCombinatorial chemistryPhotocatalysisAlkyneThiopheneSurface modificationFunctional groupPhotochemistryOrganic chemistryPolymerPhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSulfur-Based Synthesis Techniques