Borane-catalyzed cascade Friedel–Crafts alkylation/[1,5]-hydride transfer/Mannich cyclization to afford tetrahydroquinolines
Beibei Zhang, Shuo Peng, Feiyi Wang, Cuifen Lu, Junqi Nie, Zuxing Chen, Guichun Yang, Chao Ma
Abstract
-stereochemistry. The commercial availability of the catalyst and the high atom and step economy of the procedure, together with metal-free and external oxidant-free conditions, make this an attractive method in organic synthesis.
Topics & Concepts
Friedel–Crafts reactionHydrideChemistryCatalysisBoraneCascadeAlkylationTransfer hydrogenationOrganic chemistryCombinatorial chemistryHydrogenChromatographyRutheniumOrganoboron and organosilicon chemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and Analysis