IL-33 supplementation improves uterine artery resistance and maternal hypertension in response to placental ischemia
Xi Wang, Corbin A. Shields, Geilda A. Tardo, Greg Peacock, Emily Hester, Marissa Anderson, Jan M. Williams, Denise C. Cornelius
Abstract
Though decreased IL-33 signaling has been clinically associated with PE, the mechanisms linking this signaling pathway to overall disease pathophysiology are not well understood. This study provides compelling evidence that mechanistically links reduced IL-33 with the inflammatory response and vascular dysfunction observed in response to placental ischemia, such as in PE. Data presented in this study submit the IL-33 signaling pathway as a possible therapeutic target for the treatment of PE.
Topics & Concepts
PathophysiologyMedicineIschemiaSignal transductionInflammatory responseInternal medicineBioinformaticsInflammationEndocrinologyImmunologyBiologyCell biologyIL-33, ST2, and ILC PathwaysReproductive System and PregnancyEndometriosis Research and Treatment