Hydrogel nanoparticle degradation influences the activation and survival of primary macrophages
Bader M. Jarai, Zachary Stillman, Catherine A. Fromen
Abstract
The effect of nanoparticle (NP) internalization and subsequent degradation rate on cell lifespan has emerged as an important consideration for nanomedicine design, as macrophages and other phagocytes are primary clearance mechanisms of administered NP formulations.
Topics & Concepts
Degradation (telecommunications)Materials scienceNanoparticlePrimary (astronomy)Chemical engineeringBiophysicsNanotechnologyComputer scienceBiologyEngineeringTelecommunicationsPhysicsAstronomyNanoparticle-Based Drug DeliveryGraphene and Nanomaterials ApplicationsNanoparticles: synthesis and applications