Development of β,β-Dibrominated Secondary Enamides and Their Application to the Synthesis of 5-Br Oxazoles
Jun Ma, Qijie Zou, Chunhua Wang, Guangwei Yin, Fangyi Li
Abstract
Herein, we report a base promoted dibromination of enamides using CBr4 as a bromine source to provide expedient access to β,β-dibrominated secondary enamides. Preliminary synthetic application study shows that these novel products can be readily transformed to 5-Br oxazoles via Cu(I) catalyzed intramolecular cyclization in good yields.
Topics & Concepts
BromineIntramolecular forceCombinatorial chemistryChemistryBase (topology)HalogenationCatalysisOrganic chemistryMathematicsMathematical analysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsFluorine in Organic Chemistry