Radiation responsive PROTAC nanoparticles for tumor-specific proteolysis enhanced radiotherapy
Mengxia Xu, Yuyang Yun, Changjun Li, Yiling Ruan, Osamu Muraoka, Weijia Xie, Xiaolian Sun
Abstract
. We believe that this X-ray-responsive PROTAC nanomicelle could provide a new strategy for the X-ray-activated spatiotemporally controlled protein degradation and for the BRD4 proteolysis enhanced tumor radiosensitivity.
Topics & Concepts
ProteolysisNanoparticleMaterials scienceRadiationRadiation therapyDegradation (telecommunications)Cancer researchNanotechnologyComputer scienceChemistryMedicineBiochemistryInternal medicineOpticsEnzymePhysicsTelecommunicationsProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisUbiquitin and proteasome pathways