Limonin alleviates high-fat diet-induced dyslipidemia by regulating the intestinal barrier <i>via</i> the microbiota-related ILC3–IL22–IL22R pathway
Wangling Wu, Yingying Pan, Tianyan Zheng, Haoyi Sun, Xia Li, Haiyan Zhu, Zheng Wang, Xin Zhou
Abstract
. In addition, supported by flow cytometry and other analyses, we observed that limonin upregulated the ILC3-IL22-IL22R pathway, enhancing phosphorylated STAT3 (pSTAT3) in intestinal epithelial cells (IECs), thereby reducing lipid transporter expression. In conclusion, our study revealed that limonin exerted a promising preventive effect against HFD-induced dyslipidemia by the mitigation of the intestinal barrier function and intestinal microbiota, and its mechanism was related to the upregulation of the ILC3-IL22-IL22R pathway.
Topics & Concepts
DyslipidemiaInterleukin 22Gut floraCell biologyMedicineBiologyImmunologyInternal medicineDiseaseCytokineInterleukinIL-33, ST2, and ILC PathwaysHelicobacter pylori-related gastroenterology studiesEosinophilic Esophagitis