Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer’s disease model mice
Ryuichi Sekioka, Shugo Honda, Hiroki Akashiba, Junko Yarimizu, Yasuyuki Mitani, Shingo Yamasaki
Topics & Concepts
ImidazopyridineChemistryPharmacologyAmideIn vitroStereochemistryBiochemistryMedicineAlzheimer's disease research and treatmentsCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery Methods