Discovery of pyrano[2,3-<i>d</i>]pyrimidine-2,4-dione derivatives as novel PARP-1 inhibitors: design, synthesis and antitumor activity
Nour E. A. Abd El‐Sattar, Eman H. K. Badawy, Eman Z. Elrazaz, Nasser S. M. Ismail
Abstract
value of 0.66 ± 0.05 and 2.76 ± 0.06 μM, respectively. Furthermore, molecular docking of the compounds into the PARP-1 active site was performed to explore the probable binding mode. Finally, most of the synthesized compounds were predicted to have good pharmacokinetics properties in a theoretical kinetic study.
Topics & Concepts
Poly ADP ribose polymerasePyrimidineChemistryStaurosporineIC50CytotoxicityStereochemistryOlaparibDNA repairDNA damagePolymeraseCancer cellDocking (animal)Pyrimidine metabolismEnzymeBiochemistryDNACancerBiologyIn vitroGeneticsMedicineNursingPurineProtein kinase CPARP inhibition in cancer therapyCell death mechanisms and regulationIntegrated Circuits and Semiconductor Failure Analysis