Copper-catalyzed functionalization of enynes
Quentin Dherbassy, Srimanta Manna, Fabien J. T. Talbot, Watcharapon Prasitwatcharakorn, Gregory J. P. Perry, David J. Procter
Abstract
The copper-catalyzed functionalization of enyne derivatives has recently emerged as a powerful approach in contemporary synthesis. Enynes are versatile and readily accessible substrates that can undergo a variety of reactions to yield densely functionalized, enantioenriched products. In this perspective, we review copper-catalyzed transformations of enynes, such as boro- and hydrofunctionalizations, copper-mediated radical difunctionalizations, and cyclizations. Particular attention is given to the regiodivergent functionalization of 1,3-enynes, and the current mechanistic understanding of such processes.
Topics & Concepts
Surface modificationCatalysisCopperCombinatorial chemistryChemistryOrganic chemistryPhysical chemistryCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions