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MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy

Nan Yang, Xiao-Xue Li, Wenwen Huang, Gaili Ji, Wei Luo, Faming Jiang, Hao Zeng, Yali Chen, Yao Chen, Lina Qiao, Lu Chen, Shahin Rafii, Wei Wang, Ai Zheng, Bi‐Sen Ding, Zhongwei Cao

2025Nature Cell Biology8 citationsDOI

Topics & Concepts

NecroptosisImmunosurveillanceCell biologyBiologyCancerCancer researchProgrammed cell deathApoptosisTumor cellsGeneticsPhagocytosis and Immune RegulationCell death mechanisms and regulationMelanoma and MAPK Pathways
MLKL PARylation in the endothelial niche triggers angiocrine necroptosis to evade cancer immunosurveillance and chemotherapy | Litcius