Stereoselective synthesis of conjugated trienes <i>via</i> 1,4-palladium migration/Heck sequence
Ze‐Jian Xue, Mengyao Li, Bin‐Bin Zhu, Zhi‐Tao He, Chen‐Guo Feng, Guo‐Qiang Lin
Abstract
Conjugated trienes are ubiquitous structures in natural products and organic functional molecules. An efficient 1,4-palladium migration/Heck sequence was developed for the highly stereoselective synthesis of trisubstituent 1,3,5-trienes, which were found to undergo easy E/Z isomerization in the presence of light.
Topics & Concepts
StereoselectivityIsomerizationConjugated systemPalladiumSequence (biology)Heck reactionChemistryMoleculeCombinatorial chemistryOrganic chemistryStereochemistryCatalysisPolymerBiochemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions