Design, synthesis, spectroscopic characterization, computational analysis, and <i>in vitro</i> α-amylase and α-glucosidase evaluation of 3-aminopyridin-2(1<i>H</i>)-one based novel monothiooxamides and 1,3,4-thiadiazoles
Ирина В. Паламарчук, Zarina Shulgau, Adilet Y. Dautov, Shynggys Sergazy, И. В. Кулаков
Abstract
On the basis of biologically active 3-aminopyridin-2(1 H )-ones, chemical modification of derivatives of the corresponding monothiooxamides, thiohydrazides, and conjugated 1,3,4-thiadiazole derivatives has been carried out for the first time.
Topics & Concepts
ChemistryThiadiazolesIn vitroCombinatorial chemistryCharacterization (materials science)AmylaseStereochemistryEnzymeBiochemistryOrganic chemistryNanotechnologyMaterials scienceSynthesis and Characterization of Heterocyclic CompoundsSynthesis and biological activityEnzyme function and inhibition