A stable Cd-MOF as a dual-responsive luminescent biosensor for the determination of urinary diphenyl phosphate and hippuric acid as biomarkers for human triphenyl phosphate and toluene poisoning
Mingyuan Lei, Fa-Yuan Ge, Tingting Wu, Xinde Duan, Zhi‐Qiang Shi, He‐Gen Zheng
Abstract
-imidazol-1-yl)methyl)biphenyl), has been successfully synthesized, and exhibits good stability in aqueous solutions in the normal urinary pH range and real urine. Complex 1 can serve as a dual-responsive luminescent biosensor for the detection of diphenyl phosphate (DPP) and hippuric acid (HA) as biomarkers of flame retardant triphenyl phosphate and toluene poisoning, and shows the advantages of high sensitivity, rapid response, good anti-interference capability, and reversibility. More significantly, complex 1 is successfully applied to the sensitive and accurate detection of DPP and HA in real urine with satisfactory recoveries. This work presents a dual-responsive luminescent MOF-based biosensor for simple, rapid, accurate, and reversible determination of urinary DPP and HA, which has promising application potential for the diagnosis of diseases related to triphenyl phosphate and toluene poisoning.