Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization
Yuli Cheng, Yan Yu, Qinghui Zhuang, Lei Wang, Bin Zhan, Suqin Du, Yiqi Liu, Jingjing Huang, Junfeng Hao, Xinping Zhu
Abstract
, MES inhibited LPS-induced M1 macrophage activation while promoting IL-4-induced M2 macrophage polarization. Same effects of MES were also observed in monocytes derived from RA patients, wherein MES treatment suppressed LPS-induced M1 cytokine production. Moreover, MES treatment attenuated LPS and RANKL co-stimulated osteoclast differentiation from the RAW264.7 macrophages through inhibiting activation of the NF-κB rather than MAPK pathway. This study provides insight into the M1 subset as a potential target for helminths to alleviate osteoclastic bone destruction in RA.
Topics & Concepts
Trichinella spiralisRANKLOsteoclastProinflammatory cytokineMacrophage polarizationImmunologyBone resorptionMonocyteMacrophageCytokineChemistryMAPK/ERK pathwayArthritisMedicineInflammationIn vitroHelminthsInternal medicineSignal transductionActivator (genetics)ReceptorBiochemistryParasites and Host InteractionsReproductive System and PregnancySyphilis Diagnosis and Treatment