Mitochondrial Dynamics Related Genes -MFN1, MFN2 and DRP1 Polymorphisms are Associated with Risk of Lung Cancer

Abstract

Purpose: This study aimed to evaluate the associations between mitochondrial dynamics related genes - MFN1, MFN2 and DRP1 polymorphisms and risk of lung cancer. Methods: Six polymorphisms of MFN1, MFN2 and DRP1 were genotyped in 600 cases and 600 controls using a MassARRAY platform. Results: The MFN1 rs13098637-C and DRP1 rs879255689-A alleles were associated with an increased risk of lung cancer ( p rs13098637 =0.004, p rs879255689 =0.005), while MFN2 rs4240897-A and rs2236058-G were related to a decreased risk of disease ( p < 0.001). The rs13098637-TC/CC and rs879255689-GA/AA were determined as risk genotypes for lung cancer ( p rs13098637 =0.014, p rs879255689 =0.013), whereas the rs4240897-GA/AA and rs2236058-GG were identified as protective genotypes against lung cancer risk ( p < 0.001). Genetic model analysis showed that rs13098637 was correlated with an elevated risk of lung cancer in dominant and log-additive models ( p dominant =0.007, p log-additive =0.004). Moreover, rs879255689 was associated with an increased risk of disease in all three models ( p dominant =0.014, p recessive =0.028, p log-additive =0.005). In contrast, rs4240897 and rs2236058 were related to reduced risk of disease in all three models (rs4240897: p all < 0.001; rs2236058: p dominant =0.008, p recessive < 0.001, p log-additive < 0.001). In addition, these associations were related to the smoking status and pathological type of lung cancer patients. Conclusion: These results shed new light on the association between mitochondrial dynamics related genes and risk of lung cancer. Keywords: lung cancer, gene polymorphisms, mitochondrial dynamics, MFN1, MFN2

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