Multiplexed Cre-dependent selection yields systemic AAVs for targeting distinct brain cell types
Sripriya Ravindra Kumar, Timothy F. Miles, Xinhong Chen, David Alan Brown, Tatyana Dobreva, Qin Huang, Xiaozhe Ding, Yicheng Luo, Pétur Helgi Einarsson, Alon Greenbaum, Min Jee Jang, Benjamin E. Deverman, Viviana Gradinaru
Topics & Concepts
BiologyGene deliveryComputational biologyCapsidNegative selectionSelection (genetic algorithm)GeneRecombinant DNACell typeTransduction (biophysics)Genetic enhancementCellGeneticsGenomeComputer scienceArtificial intelligenceBiochemistryCRISPR and Genetic EngineeringViral Infectious Diseases and Gene Expression in InsectsVirus-based gene therapy research