<i>In situ</i>one-step synthesis of polymer-functionalized palladium nanoparticles: an efficient anticancer agent against breast cancer
Vaikundamoorthy Ramalingam, Sakthivel Raja, Harshavardhan Mohan
Abstract
band modes of PVP. Microscopic analysis showed that the PVP-PdNPs have a narrow size distribution with spherical shapes and a size range between 9 and 15 nm. The SAED and XRD patterns confirmed that the crystalline structure is face-centered cubic in nature, and EDAX mapping confirmed the formulation of PVP on the surface of the PdNPs. Further, in vitro MTT assay analysis showed that the PVP-PdNPs exhibit excellent cytotoxic activity against human breast cancer MCF7 cells in a dose-dependent manner. The PVP-PdNPs generate continuous ROS in the mitochondria; this leads to the damage of the mitochondrial membrane potential and nuclear DNA and induces apoptosis through caspase3/7 enzymatic activity. Together, the PVP-PdNPs are a promising potential anticancer agent against human breast cancer.