NT157, an IGF1R-IRS1/2 inhibitor, exhibits antineoplastic effects in pre-clinical models of chronic myeloid leukemia
Renata Scopim‐Ribeiro, João Agostinho Machado‐Neto, Christopher A. Eide, Juan Luiz Coelho‐Silva, Bruna Alves Fenerich, Jaqueline Cristina Fernandes, Priscila Santos Scheucher, Samantha L. Savage, Paula de Melo Campos, Sara Teresinha Olalla Saad, Leonardo de Carvalho Palma, Lorena Lobo de Figueiredo‐Pontes, Belinda Pinto Simões, Eduardo Magalhães Rego, Cristina E. Tognon, Brian Druker, Fabı́ola Traina
Topics & Concepts
Myeloid leukemiaCancer researchImatinibK562 cellsPI3K/AKT/mTOR pathwayTyrosine kinaseInsulin-like growth factor 1 receptorChronic myelogenous leukemiabreakpoint cluster regionImatinib mesylateCell growthApoptosisBiologyHaematopoiesisLeukemiaTyrosine-kinase inhibitorStem cellImmunologySignal transductionReceptorCell biologyCancerGrowth factorBiochemistryGeneticsChronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia ResearchAcute Myeloid Leukemia Research