Nrf2 Suppresses Oxidative Stress and Inflammation in <i>App</i> Knock-In Alzheimer’s Disease Model Mice
Akira Uruno, Daisuke Matsumaru, Rie Ryoke, Ritsumi Saito, Shiori Kadoguchi, Daisuke Saigusa, Takashi Saito, Takaomi C. Saido, Ryuta Kawashima, Masayuki Yamamoto
Abstract
mice in the passive-avoidance task. These results demonstrate that the induction of Nrf2 ameliorates cognitive impairment in the AD model mouse by suppressing oxidative stress and neuroinflammation, suggesting that Nrf2 is an important therapeutic target of AD.
Topics & Concepts
Oxidative stressGene knockinNeuroinflammationBiologyInflammationEndocrinologyGlutathioneInternal medicineMicrogliaKnockout mouseImmunologyBiochemistryMedicineGeneEnzymeGenomics, phytochemicals, and oxidative stressTryptophan and brain disordersNeuroinflammation and Neurodegeneration Mechanisms