Electrochemical oxidative decarboxylation and 1,2-aryl migration towards the synthesis of 1,2-diaryl ethers
Faxiang Bu, Lijun Lu, Xia Hu, Shengchun Wang, Heng Zhang, Aiwen Lei
Abstract
Carboxylic acid compounds are important chemicals and are widely present in various natural products. They are not only nucleophiles, but also radical precursors. Classic transition-metal-catalyzed and photochemical decarboxylation have shown their excellent site selectivity in radical chemistry. However, electrochemical decarboxylation with a long history hasn't got enough attention in recent years. In this work, the electrochemical oxidative decarboxylation and 1,2-aryl migration of 3,3-diarylpropionic acids have been introduced to construct C-O bonds with alcohols. Remarkably, this transformation can proceed smoothly without metal catalysts and external oxidants.
Topics & Concepts
DecarboxylationChemistryElectrochemistryArylCarboxylic acidOxidative decarboxylationOxidative phosphorylationOrganic chemistryCombinatorial chemistryCatalysisBiochemistryElectrodePhysical chemistryAlkylRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsSulfur-Based Synthesis Techniques