Paracrine HGF promotes EMT and mediates the effects of PSC on chemoresistance by activating c-Met/PI3K/Akt signaling in pancreatic cancer in vitro
Jianfei Xu, Shanglong Liu, Xiaopeng Yang, Shougen Cao, Yanbing Zhou
Topics & Concepts
Hepatocyte growth factorParacrine signallingPI3K/AKT/mTOR pathwayProtein kinase BC-MetCancer researchPancreatic cancerChemistryEpithelial–mesenchymal transitionVimentinLY294002Signal transductionMolecular biologyBiologyInternal medicineReceptorCancerImmunologyMedicineDownregulation and upregulationBiochemistryImmunohistochemistryGeneLiver physiology and pathologyCancer Cells and MetastasisProteoglycans and glycosaminoglycans research