A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS
Xiaohua Duan, Tuo Zhang, Lingling Feng, Neranjan de Silva, Benjamin C. Greenspun, Xing Wang, Jenna E. Moyer, M. Laura Martin, Rohit Chandwani, Olivier Elemento, Steven D. Leach, Todd Evans, Shuibing Chen, Fong Cheng Pan
Topics & Concepts
OrganoidBiologyKRASPancreatic cancerMutantCancer researchComputational biologyCancerCell biologyBioinformaticsGeneticsGeneColorectal cancerPancreatic and Hepatic Oncology ResearchCaveolin-1 and cellular processesFOXO transcription factor regulation