Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Kristen E. Pauken, Morgan A. Sammons, Pamela M. Odorizzi, Sasikanth Manne, Jernej Godec, Omar Khan, Adam Drake, Zeyu Chen, Debattama R. Sen, Makoto Kurachi, R. Anthony Barnitz, Caroline Bartman, Bertram Bengsch, Alexander C. Huang, Jason M. Schenkel, Golnaz Vahedi, W. Nicholas Haining, Shelley L. Berger, E. John Wherry
Abstract
epigenetic landscape. These data indicate that epigenetic fate inflexibility may limit current immunotherapies.
Topics & Concepts
BlockadeDurabilityEpigeneticsStability (learning theory)ChemistryComputer scienceReceptorGeneBiochemistryDatabaseMachine learningImmune Cell Function and InteractionT-cell and B-cell ImmunologyImmunotherapy and Immune Responses