Design, synthesis and biological evaluation of structurally new 4-indolyl quinazoline derivatives as highly potent, selective and orally bioavailable EGFR inhibitors
Pengxing He, Linna Du, Qing-Qing Dai, Guo‐Bo Li, Bin Yu, Linlin Chang
Topics & Concepts
ChemistryEpidermal growth factor receptorEGFR inhibitorsQuinazolineIC50In vivoPharmacologyKinaseCell growthProtein kinase BCancer researchGrowth inhibitionIn vitroApoptosisReceptorBiochemistryMedicineBiologyStereochemistryBiotechnologyQuinazolinone synthesis and applicationsLung Cancer Treatments and MutationsCancer Mechanisms and Therapy