Litcius/Paper detail

Inhibition of GPX4 or mTOR overcomes resistance to Lapatinib via promoting ferroptosis in NSCLC cells

Jiangwei Ni, Kun Chen, Jiandong Zhang, Xiang Zhang

2021Biochemical and Biophysical Research Communications88 citationsDOI

Topics & Concepts

GPX4Downregulation and upregulationCancer researchmTORC1Epidermal growth factor receptorA549 cellChemistryPI3K/AKT/mTOR pathwayGlutathioneApoptosisBiologyGlutathione peroxidaseReceptorBiochemistryGeneEnzymeFerroptosis and cancer prognosisRNA modifications and cancerEpigenetics and DNA Methylation
Inhibition of GPX4 or mTOR overcomes resistance to Lapatinib via promoting ferroptosis in NSCLC cells | Litcius