Regio- and stereo-selective olefinic C–H functionalization of aryl alkenes in ethanol
Cong Shen, Yuhang Zhu, Shuqi Jin, Kejie Xu, Shuxin Luo, Lixia Xu, Guofu Zhong, Liangjun Zhong, Jian Zhang
Abstract
We report on α- and β-olefinic C–H alkenylation of 2-alkenyl benzylamine/benzoic acid derivatives in ethanol to afford aryl dienes/trienes with excellent selectivities, proceeding through 6-/7-membered exo -/ endo -cyclometallation.
Topics & Concepts
ChemistryBenzylamineArylEthanolSurface modificationBenzoic acidOrganic chemistryMedicinal chemistryPhysical chemistryAlkylCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCatalytic Cross-Coupling Reactions