Nickel‐Catalyzed Thiolation of Aryl Nitriles
Tristan Delcaillau, Bill Morandi
Abstract
Abstract A nickel‐catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers. The ligand dcype (1,2‐bis(dicyclohexylphosphino)ethane) as well as the base KO t Bu (potassium tert ‐butoxide) are essential to achieve this transformation. This scalable and practical process involves both a C−C bond activation and a C−S bond formation. Furthermore, this reaction shows a high functional‐group tolerance and enables the late‐stage functionalization of important molecules.
Topics & Concepts
ArylCatalysisNickelChemistryCombinatorial chemistryLigand (biochemistry)Surface modificationMoleculeTransformation (genetics)PotassiumOrganic chemistryReceptorBiochemistryPhysical chemistryGeneAlkylSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods