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Gallic acid impairs fructose-driven de novo lipogenesis and ameliorates hepatic steatosis via AMPK-dependent suppression of SREBP-1/ACC/FASN cascade

Yuzhen Lu, Cong Zhang, Yingying Song, Liang Chen, Xin Chen, Guohua Zheng, Yuan Yang, Peng Cao, Zhenpeng Qiu

2022European Journal of Pharmacology35 citationsDOI

Topics & Concepts

LipogenesisAMPKFatty acid synthaseSteatosisNonalcoholic fatty liver diseaseCarbohydrate-responsive element-binding proteinInternal medicineEndocrinologyChemistryFatty liverFatty acid synthesisAMP-activated protein kinaseSterol regulatory element-binding proteinProtein kinase AFatty acidBiologyBiochemistryMedicineKinaseAdipose tissueTranscription factorSterolCholesterolGeneDiseaseLiver Disease Diagnosis and TreatmentDiet, Metabolism, and DiseaseLipid metabolism and biosynthesis
Gallic acid impairs fructose-driven de novo lipogenesis and ameliorates hepatic steatosis via AMPK-dependent suppression of SREBP-1/ACC/FASN cascade | Litcius