Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle
Tatsuro Egawa, Takeshi Ogawa, Takumi Yokokawa, Kohei Kido, Katsumasa Goto, Tatsuya Hayashi
Abstract
This study investigated the effect of methylglyoxal, which is a highly reactive carbonyl metabolite and has detrimental effects on the body, on skeletal muscle adaptations following endurance exercise. Evidences from this study show that methylglyoxal is a factor deteriorating responsiveness to endurance exercise in primarily fast-twitch skeletal muscle. The findings contribute to understand the internal factors that should be focused to maximize the exercise effects.
Topics & Concepts
Mitochondrial biogenesisMethylglyoxalInternal medicineEndocrinologySkeletal muscleGlycationInsulin resistancePlantaris muscleEndurance trainingCitrate synthaseInsulin receptorSoleus muscleCarbohydrate metabolismBiologyChemistryMitochondrionReceptorInsulinMedicineBiochemistryEnzymeAdipose Tissue and MetabolismMuscle metabolism and nutritionExercise and Physiological Responses