Deoxygenative Cyanofunctionalization of Aldehydes and Ketones Enabled by Electrochemical Reduction
Yi Wang, Bofei Wang, Song Lin
Abstract
The deoxygenative difunctionalization of carbonyls converts readily available carbonyl compounds into value-added gem -difunctionalized building blocks. We report an electrochemical carbonyl umpolung approach for the deoxygenative cyanofunctionalization of aldehydes and ketones, affording various α-functionalized nitriles. Further derivatization of these products provides a versatile and modular platform for geminal disubstitution of carbonyl oxygens.
Topics & Concepts
ChemistryUmpolungDerivatizationGeminalElectrochemistryOrganic chemistryAldehydeReduction (mathematics)Combinatorial chemistryAcylationAliphatic compoundChemical reductionKetoneOxidation reductionAlkylationRadical Photochemical ReactionsSulfur-Based Synthesis TechniquesOxidative Organic Chemistry Reactions