Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel
Winka Le Clecʼh, Frédéric D. Chevalier, Ana Carolina Alves de Mattos, Amanda Strickland, Robbie Diaz, Marina McDew‐White, Claudia M. Rohr, Safari Kinung’hi, Fiona Allan, Bonnie L. Webster, Joanne P. Webster, Aidan M. Emery, David Rollinson, Amadou Garba Djirmay, Khalid M. Al Mashikhi, Salem Al Yafae, Mohamed A. Idris, Hélène Moné, Gabriel Mouahid, Philip T. LoVerde, Jonathan S. Marchant, Timothy J. C. Anderson
Abstract
and provides an approach for monitoring emerging PZQ-resistant alleles in schistosome elimination programs.
Topics & Concepts
PraziquantelSchistosoma mansoniBiologyGeneticsDrug resistancePopulationSchistosomiasisImmunologyHelminthsMedicineEnvironmental healthParasites and Host InteractionsTrace Elements in HealthParasite Biology and Host Interactions