Inhibition of IKKβ/NF-κB signaling facilitates tendinopathy healing by rejuvenating inflamm-aging induced tendon-derived stem/progenitor cell senescence
Chongyang Wang, Zhekun Zhou, Wei Song, Zhuochang Cai, Zhenyu Ding, Daoyun Chen, Fangfang Xia, Yaohua He
Abstract
. Thus, our study provides a promising therapeutic strategy for degenerative RCT via intra-articular delivery of IKKβ siRNA using AuNCs.
Topics & Concepts
SenescenceIκB kinaseProgenitor cellInflammationCell biologySmall interfering RNAStem cellMedicineCancer researchMesenchymal stem cellNF-κBBiologyImmunologyCell cultureTransfectionGeneticsTendon Structure and TreatmentShoulder Injury and TreatmentSports injuries and prevention