The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4 <sup>+</sup> T Cells via a Novel CDK8-GATA3-FOXP3 Pathway
Azlann Arnett, Keagan G. Moo, Kaitlin J. Flynn, Thomas B. Sundberg, Liv Johannessen, Alykhan F. Shamji, Nathanael S. Gray, Thomas Decker, Ye Zheng, Vivian H. Gersuk, Ziaur S. M. Rahman, David E. Levy, Isabelle Marié, Peter S. Linsley, Ramnik J. Xavier, Bernard Khor
Abstract
differentiation and their temporal sequencing. These findings have significant implications for future mechanistic and translational studies of CDK8 and CDK8 inhibitors.
Topics & Concepts
BiologyFOXP3Cell biologyCyclin-dependent kinase 8Immune systemAcquired immune systemCellular differentiationInnate immune systemTranscription factorImmunophenotypingGATA3KinaseSignal transductionImmunologyGeneticsFlow cytometryGeneNotch signaling pathwayImmune Cell Function and InteractionImmune cells in cancerSingle-cell and spatial transcriptomics