Echinocandins Localized to the Target-Harboring Cell Surface Are Not Degraded but Those Entering the Vacuole Are
Qais Z. Jaber, Dana Logviniuk, Adi Yona, Micha Fridman
Abstract
cells revealed substantial degradation over time; functional vacuoles were necessary for this degradation. Under the same conditions, fluorescent ANF was not degraded. This study supports the "target-oriented drug subcellular localization" principle. In the case of echinocandins, localization to the cell surface can contribute to improved potency and accumulation in vacuoles induces degradation leading to drug deactivation.
Topics & Concepts
VacuoleEchinocandinsCell biologyCellChemistryBiologyBiophysicsBiochemistryMicrobiologyCytoplasmAntifungalCaspofunginAmphotericin BStudies on Chitinases and ChitosanasesParasitic Diseases Research and TreatmentAntifungal resistance and susceptibility