Enhancing Temozolomide (TMZ) chemosensitivity using CRISPR-dCas9-mediated downregulation of O6-methylguanine DNA methyltransferase (MGMT)
Yasamin Yousefi, Reza Nejati, Atiye Eslahi, Farzaneh Alizadeh, Shima Farrokhi, Ahmad Asoodeh, Majid Mojarrad
Topics & Concepts
TemozolomideMethyltransferaseO-6-methylguanine-DNA methyltransferaseDownregulation and upregulationCRISPRDNA methyltransferaseCancer researchChemistryDNAGlioblastomaBiologyMethylationGeneBiochemistryGlioma Diagnosis and TreatmentHistone Deacetylase Inhibitors ResearchBrain Metastases and Treatment